The report presents an analysis of results of the plumb-line deflection components in Western Siberia territory obtained by modern global geopotential models data, terrestrial data, GNSSleveling and geometric leveling with the results of astronomo-geodetic measurements. The part of Novosibirsk Region was used as a test area for comparison of determination results of the plumbline deflection components calculated by the method of numerical differentiation. According to comparison results of the astronomo-geodetic plumb-line deflection to results of the plumb-line deflection obtained by numerical differentiation method of geoid undulation in the test area, geoid surface that is constructed on harmonic coefficients of global geopotential model EIGEN-6C4 makes it possible to determine the plumb-line deflection with the root mean square ±0,34''. The obtained results make it possible to determine plumb-line deflection for solving scientific and practical problems of geodesy and autonomous navigation by numerical differentiation of geoid undulation obtained from the coefficients of global geopotential model.