The author describes the performed GIS-analysis of the Central Asian transportation systems. The road transportation infrastructure of the whole region and its individual countries (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) has been studied. The overview of the factors, influencing the formation of regional transportation systems, including historical, political and natural, has been done. The road network of Central Asian countries has been modeled using GIS network analysis toolset, with spatial data provided by OpenStreetMap. The so-called topological tiers of the network have been identified, showing the uneven provision of the studied area with road transport infrastructure. The proposed research method makes it possible to note a high degree of the road network integration between the countries. The areas with low transport accessibility, as well as autonomous parts of road network have been visualized. The research categorizes the countries’ transport networks configurations types formed under the influence of economic, social, agricultural, climatic and topographical factors.