The relevance of the research lies in the study of the relationship between the morphometry of the relief with ore occurrences and deposits. Its purpose is to quantify the physical (topographic) surface of the Earth in order to identify tectonic structures with subsequent rational planning of geological exploration based on determining the morphometry of the work area by comparison with identical natural structures. The object of the study is the region of the Dnieper-Donets aulacogen with the northwest-southeast direction Kharkov- the Caspian Sea and the north-south one from Millerovo to Rostov-on-Don. As research methods we chose selection of neotectonic structures according to the method of V. P. Filosofov, using the construction of isobasic and iso-vertex surfaces of different orders, followed by subtraction of the former from the latter to calculate the relief energy. DEM SRTM3 (90 m/pixel) and ArcGIS v. 10.8 software were used as a basis. The result is presented in the form of cartographic diagrams of 1–4 orders relief energies subtractions from the modern surface, according to which a rise elongated in the north-west direction is determined. Various deposits and ore occurrences are noted, concentrated mainly in zones of higher relief energy at the foot of the identified uplift with complicating ore control structures in the form of thrusts and discharges. Areas with maximal indicators have more pronounced geological processes on the surface, leading to a change in the locality and creating conditions for exposing buried ore accumulations